Trifluridine-13C,15N2

Names

[ CAS No. ]:
2086328-10-9

[ Name ]:
Trifluridine-13C,15N2

Biological Activity

[Description]:

Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase
Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HSV
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.  

Chemical & Physical Properties

[ Molecular Formula ]:
C913CH11F315N2O5

[ Molecular Weight ]:
299.18

Related Compounds