2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

Names

[ CAS No. ]:
2086689-05-4

[ Name ]:
2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

[Synonym ]:
3,6,9,16-Tetraoxa-13-azanonadecan-19-oic acid, 1-azido-14-[(2-carboxyethoxy)methyl]-12-oxo-
1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid

Biological Activity

[Description]:

2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₂N₄O₁₀

[ Molecular Weight ]:
464.467

[ Exact Mass ]:
464.211853

[ LogP ]:
-1.20