Bcl-2/Mcl-1-IN-3

Names

[ CAS No. ]:
2088981-53-5

[ Name ]:
Bcl-2/Mcl-1-IN-3

Biological Activity

[Description]:

Bcl-2/Mcl-1-IN-3 (compound 1) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.14 μM and 0.23 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Mcl-1:0.14 μM (Ki)

Bcl-2:0.23 μM (Ki)

Bcl-xL:15 μM (Ki)

[References]

[1]. Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆ClNO₄

[ Molecular Weight ]:
463.95

Bcl-2/Mcl-1-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds