sAJM-589

Names

[ CAS No. ]:
2089-82-9

[ Name ]:
sAJM-589

[Synonym ]:
3-Hydroxy-1,2-benzophenazin

Biological Activity

[Description]:

sAJM-589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> c-Myc

[Target]

IC50: 1.8 μM (Myc)[1]

[In Vitro]

sAJM-589 potently disrupts the Myc-Max heterodimer in a dose dependent manner with an IC50of 1.8 μM[1]. sAJM589 suppresses cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells[1].

[References]

[1]. Choi SH, et al. Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₀N₂O

[ Molecular Weight ]:
246.26300

[ Exact Mass ]:
246.07900

[ PSA ]:
46.01000

[ LogP ]:
3.64180

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%