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VT-1598

Names

[ CAS No. ]:
2089320-99-8

[ Name ]:
VT-1598

[Synonym ]:
Benzonitrile, 4-[[4-[2-[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl]-3-pyridinyl]ethynyl]phenoxy]methyl]-
Vt-1598
4-{[4-({6-[2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl]-3-pyridinyl}ethynyl)phenoxy]methyl}benzonitrile

Biological Activity

[Description]:

VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.

[References]

References 1. Hargrove TY, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17. 2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. 3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408. View Related Products by Target Fungal

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
770.9±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H20F4N6O2

[ Molecular Weight ]:
584.523

[ Flash Point ]:
420.0±35.7 °C

[ Exact Mass ]:
584.158386

[ LogP ]:
6.56

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.614

Related Compounds