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(R)-ZINC 3573

Names

[ CAS No. ]:
2089389-15-9

[ Name ]:
(R)-ZINC 3573

[Synonym ]:
(R)-ZINC-3573
3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-
(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
(R)-ZINC72453573
(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

Biological Activity

[Description]:

(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases; activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

[References]

References 1. Lansu K, et al. Nat Chem Biol. 2017 May;13(5):529-536. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C18H21N5

[ Molecular Weight ]:
307.393

[ Exact Mass ]:
307.179688

[ LogP ]:
1.36

[ Index of Refraction ]:
1.671

[ Storage condition ]:
2-8°C

Related Compounds