Dyrk1A-IN-4

Names

[ CAS No. ]:
2091883-59-7

[ Name ]:
Dyrk1A-IN-4

Biological Activity

[Description]:

Dyrk1A-IN-4 (compound 48) is a potent and orally active DYRK1A and DYRK2 inhibitor with IC50s of 2 nM and 6 nM, respectively. Dyrk1A-IN-4 has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

[Target]

DYRK1A:2 nM (IC50)

DYRK2:6 nM (IC50)

[References]

[1]. Csaba Weber, et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021 May 27;64(10):6745-6764.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₃F₃N₆

[ Molecular Weight ]:
322.29

Dyrk1A-IN-4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds