m-PEG8-(CH2)12-phosphonic acid

Names

[ CAS No. ]:
2093153-86-5

[ Name ]:
m-PEG8-(CH2)12-phosphonic acid

Biological Activity

[Description]:

m-PEG8-C10-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₅₇O₁₁P

[ Molecular Weight ]:
588.71

[ Storage condition ]:
2-8°C

m-PEG8-(CH2)12-phosphonic acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds