Thalidomide-NH-C4-NH-Boc

Names

[ CAS No. ]:
2093388-52-2

[ Name ]:
Thalidomide-NH-C4-NH-Boc

Biological Activity

[Description]:

Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈N₄O₆

[ Molecular Weight ]:
444.48

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-NH-C4-NH-Boc

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds