SNIPER(BRD)-1

Names

[ CAS No. ]:
2095244-54-3

[ Name ]:
SNIPER(BRD)-1

Biological Activity

[Description]:

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4

cIAP1:6.8 nM (IC50)

cIAP2:17 nM (IC50)

XIAP:49 nM (Ki)

SNIPER

[References]

[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₆₆ClN₉O₈S₂

[ Molecular Weight ]:
1056.73

SNIPER(BRD)-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds