TP-030-1

Names

[ CAS No. ]:
2095514-75-1

[ Name ]:
TP-030-1

Biological Activity

[Description]:

TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

TP-030-1 inhibits HT29 necroptosis with an IC50 value of 18 nM[1]. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM[1]. TP-030-1 inhibits mRIPK1 with an IC50 value of 4.2 μM[1].

[References]

[1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂N₄O₃

[ Molecular Weight ]:
402.45

TP-030-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds