eIF4A3-IN-2

Names

[ CAS No. ]:
2095677-20-4

[ Name ]:
eIF4A3-IN-2

Biological Activity

[Description]:

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

[Target]

IC50: 110 nM (eIF4A3)[1]

[In Vitro]

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities[1].

[References]

[1]. Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₁₉Br₂ClN₄O₂

[ Molecular Weight ]:
602.70

[ Storage condition ]:
2-8℃

eIF4A3-IN-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds