CHK1-IN-3

Names

[ CAS No. ]:
2097252-39-4

[ Name ]:
CHK1-IN-3

Biological Activity

[Description]:

CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)

[Target]

Chk1:0.4 nM (IC50)

[In Vitro]

CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM) and displays low affinity for hERG (IC50 > 40 µM)[1].

[In Vivo]

CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected[1].

[References]

[1]. Tong L, et al. Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₉O

[ Molecular Weight ]:
405.46

CHK1-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds