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Hydroxypyruvic acid lithium hydrate

Names

[ CAS No. ]:
209728-15-4

[ Name ]:
Hydroxypyruvic acid lithium hydrate

Biological Activity

[Description]:

Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

IC50: intermediate; substrate


[In Vivo]

Hydroxypyruvic acid (lithium hydrate) (intravenous injection; 100 mg/ml; slowly over 10 min) increases the 5-h urinary oxalate and glycolate excretion to 0.68% (6.56 μmol) and 0.53% (5.10 μmol) in control rats, in addition, it increases to 2.43% (23.36 μmol) and 0.79% (7.59 μmol) of the dose in the vitamin-B6-deficient rats[1].

[References]

[1]. Teerajetgul Y, et al. Oxalate synthesis from hydroxypyruvate in vitamin-B6-deficient rats.Urol Res. 2007 Aug;35(4):173-8. Epub 2007 Jun 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C3H5LiO5

[ Molecular Weight ]:
128.01


Related Compounds