N-(Amino-PEG4)-N-Biotin-PEG4-acid

Names

[ Name ]:
N-(Amino-PEG4)-N-Biotin-PEG4-acid

Biological Activity

[Description]:

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₅₈N₄O₁₂S

[ Molecular Weight ]:
710.88

Safety Information

[ Hazard Codes ]:
Xi

N-(Amino-PEG4)-N-Biotin-PEG4-acid

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds