EML-633

Names

[ CAS No. ]:
2101954-85-0

[ Name ]:
EML-633

Biological Activity

[Description]:

A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 2 uM; shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.

[References]

References 1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377. 2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₆₂N₆O₂

[ Molecular Weight ]:
682.998

Related Compounds

EML-631
EML 425
EML-405
KRN-633
DKFZ-633
1,5-Naphthalenedisulfonic acid, 2-[2-[8-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-1-hydroxy-3,6-disulfo-2-naphthalenyl]diazenyl]-, sodium salt (1:), reaction products with sodium 2,4-diamino-5-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]benzenesulfonate (1:)
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
2-chloro-4-(1,3-dimethyl-1H-pyrazol-4-yl)Pyrimidine
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide