MDTF free acid

Names

[ CAS No. ]:
2102021-49-6

[ Name ]:
MDTF free acid

Biological Activity

[Description]:

MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[In Vitro]

MDTF free acid (50 μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe[1].

[References]

[1]. Dovgan I, et, al. 2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep. 2016 Aug 9;6:30835.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₁F₄NO₉S

[ Molecular Weight ]:
469.32

MDTF free acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds