4-(4-nitro-phenyl)-thiazol-2-ylamine

Names

[ Name ]:
4-(4-nitro-phenyl)-thiazol-2-ylamine

[Synonym ]:
2-Thiazolamine,4-(4-nitrophenyl)
4-(4-NITRO-PHENYL)-THIAZOL-2-YLAMINE
2-Amino-4-(4-nitrophenyl)thiazole
4-(4-NITROPHENYL)THIAZOL-2-AMINE
2-Amino-4-(p-nitrophenyl)thiazole
4-(4-NITROPHENYL)-1,3-THIAZOLE-2-YLAMINE
4-(4-Nitrophenyl)-2-thiazolamine
2-AMINO-4-(4-NITROPHENYL)-1,3-THIAZOLE
THIAZOLE,2-AMINO-4-(p-NITROPHENYL)
2-amino-4-(4'-nitrophenyl)-1,3-thiazole
2-THIAZOLAMINE,4-(4-NITROPHENYL)-
4-(4-NITROPHENYL)-2-THIAZOLYLAMINE
4-(4-NITROPHENYL)THIAZOL-2-YLAMINE
MFCD00170222

Chemical & Physical Properties

[ Density]:
1.459g/cm3

[ Boiling Point ]:
448.4ºC at 760 mmHg

[ Melting Point ]:
283-287ºC

[ Molecular Formula ]:
C₉H₇N₃O₂S

[ Molecular Weight ]:
221.23600

[ Flash Point ]:
225ºC

[ Exact Mass ]:
221.02600

[ PSA ]:
112.97000

[ LogP ]:
3.40490

[ Vapour Pressure ]:
3.11E-08mmHg at 25°C

[ Index of Refraction ]:
1.692

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ2860000

CHEMICAL NAME :: Thiazole, 2-amino-4-(p-nitrophenyl)-

CAS REGISTRY NUMBER :: 2104-09-8

BEILSTEIN REFERENCE NO. :: 0200321

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N3-O2-S

MOLECULAR WEIGHT :: 221.25

WISWESSER LINE NOTATION :: T5N CSJ BZ ER DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2150 mg/kg/13W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,841,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9600 mg/kg/46W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,1593,1973

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XJ2860000

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Mass spectrometry of 2-substituted-4-arylthiazoles. II--Identification of microsomal nitroreduction product by mass spectrometry.

Biomed. Mass Spectrom. 9(9) , 376-80, (1982)

Electron impact fragmentation of 2-methyl-4-(4-nitrophenyl)-thiazole and 2-amino-4-(4-nitrophenyl)-thiazoles were studied. Prominent fragment ions result from: (1) elimination of an NO2 radical and of...