Clothianidin

Names

[ Name ]:
Clothianidin

[Synonym ]:
TI 435
1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine
Pancho
3-(2-chloro-5-thiazolylmethyl)-1-methyl-2-nitroguanidine
(E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine
[C(E)]-N-[(2-Chloro-5-thiazolyl)methyl]-N′-methyl-N″-nitroguanidine
Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N''-methyl-N'-nitro-
Poncho
1-(2-chlorothiazol-5-ylmethyl)-2-nitro-3-methyl-guanidine
Dantop
MFCD06200753
1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)
(E)-1-(2-CHLORO-5-THIAZOLYLMETHYL)-3-METHYL-2-NITROGUANIDINE
(E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine
(E)-1-(2-chlorothiazol-5-ylmethyl)-3-methyl-2-nitroguanidine
1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine
Clothianidin
Apacz
T5N CSJ BG D1MYM1&UNNW &&E Form
N-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitro-guanidine
Celero
Belay
Clutch
Dantotsu
1-[(2-chloro-5-thiazolyl)methyl]-3-methyl-2-nitroguanidine

Biological Activity

[Description]:

Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Clothianidin (30 nM) 在离体神经元上表现出高活性[2]。 Clothianidin (1 µg/L；36 h) 对马利筋中的帝王蝶幼虫显示出亚致死效应[3]。 Clothianidin (0.25 mg/粒和 0.50 mg/粒) 在玉米和大豆耕作的农田中，在土壤和水中浓度低[4]。

[References]

[1]. Uneme H. Chemistry of clothianidin and related compounds. J Agric Food Chem. 2011 Apr 13;59(7):2932-7.

[2]. Nauen R, et al. Thiamethoxam is a neonicotinoid precursor converted to clothianidin in insects and plants[J]. Pesticide biochemistry and physiology, 2003, 76(2): 55-69.

[3]. Pecenka JR, et al. Non-target effects of clothianidin on monarch butterflies. Naturwissenschaften. 2015 Apr;102(3-4):19.

[4]. de Perre C, et al. Fate and effects of clothianidin in fields using conservation practices. Environ Toxicol Chem. 2015 Feb;34(2):258-65.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
435.2±55.0 °C at 760 mmHg

[ Melting Point ]:
178.8 °C

[ Molecular Formula ]:
C₆H₈ClN₅O₂S

[ Molecular Weight ]:
249.678

[ Flash Point ]:
217.0±31.5 °C

[ Exact Mass ]:
249.008728

[ PSA ]:
123.37000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.709

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
327 MG/L AT 20 ºC

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P301 + P312 + P330-P391-P501

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S22:Do not breathe dust .

[ RIDADR ]:
UN2811

[ WGK Germany ]:
3

[ RTECS ]:
ME9565000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2934100016

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934100016

[ Summary ]:
2934100016 (z)-1-((2-chlorothiazol-5-yl)methyl)-2-methyl-3-nitroguanidine。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

Capillary electrophoresis-mass spectrometry as a new approach to analyze neonicotinoid insecticides.

J. Chromatogr. A. 1359 , 317-24, (2014)

This paper represents the first report of a capillary electrophoresis (CE) method compatible with mass spectrometry (MS) detection for simultaneously analyzing seven neonicotinoid insecticides (acetam...

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

A simultaneous extraction method for organophosphate, pyrethroid, and neonicotinoid insecticides in aqueous samples.

Arch. Environ. Contam. Toxicol. 68(4) , 745-56, (2015)

A method was developed for the extraction and analysis of 2 organophosphate, 8 pyrethroid, and 5 neonicotinoid insecticides from the same water sample. A salted liquid-liquid extraction (LLE) was opti...