BRD-4592

Names

[ Name ]:
BRD-4592

Biological Activity

[Description]:

A small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB); binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively; highly effective in vivo.

[References]

References 1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅FN₂O

[ Molecular Weight ]:
282.318

Related Compounds

brd-in-3
BRD 8184
BRD 8430
BRD 4354
BRD-K98645985
BRD 73954
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
tert-butyl N-{2-[(1R)-2-amino-1-hydroxyethyl]-4-fluorophenyl}carbamate
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
2-(3-Bromo-4-methylthiophen-2-yl)prop-2-en-1-amine