UMB-136
Names
[ CAS No. ]:
2109805-83-4
[ Name ]:
UMB-136
[Synonym ]:
N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine
Imidazo[1,2-a]pyrazin-3-amine, N-cyclohexyl-2-[4-(3,5-dimethyl-4-isoxazolyl)-2-methoxyphenyl]-
Biological Activity
[Description]:
A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation; dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association; enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.
[References]
References 1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035. View Related Products by Target Bromodomain
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C24H27N5O2
[ Molecular Weight ]:
417.504
[ Exact Mass ]:
417.216461
[ LogP ]:
3.83
[ Index of Refraction ]:
1.675