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Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

Names

[ CAS No. ]:
211439-12-2

[ Name ]:
Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

[Synonym ]:
L-Glutamine, L-asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-
UNII:GF00K3IIWE
davunetide
L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine
NAPVSIPQ

Biological Activity

[Description]:

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Research Areas >> Neurological Disease

[In Vivo]

Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3]. Animal Model: Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)[3] Dosage: 2 μg/kg Administration: Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks Result: Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.

[References]

[1]. Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842.

[2]. Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats. Physiol Behav. 2017;174:67-73.

[3]. Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1333.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C36H60N10O12

[ Molecular Weight ]:
824.921

[ Flash Point ]:
760.5±34.3 °C

[ Exact Mass ]:
824.439209

[ LogP ]:
-1.78

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.566

[ Storage condition ]:
-20°C

Related Compounds