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PARP-2-IN-1

Names

[ CAS No. ]:
2115698-83-2

[ Name ]:
PARP-2-IN-1

Biological Activity

[Description]:

PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP-2:11.5 nM (IC50)

[References]

[1]. Zhao H, et al. Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors. Bioorg Med Chem. 2017 Aug 1;25(15):4045-4054.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉F₄N₅O₃

[ Molecular Weight ]:
465.40

Related Compounds