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Nampt-IN-3

Names

[ CAS No. ]:
2121591-52-2

[ Name ]:
Nampt-IN-3

Biological Activity

[Description]:

Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H25N7O2

[ Molecular Weight ]:
503.55

Related Compounds