ST-168
Names
[ CAS No. ]:
2126038-25-1
[ Name ]:
ST-168
Biological Activity
[Description]:
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively; exhibits improved inhibition toward PI3K isoforms compared to ST-162; demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.
[References]
References 1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813. View Related Products by Target PI3K
Chemical & Physical Properties
[ Molecular Formula ]:
C41H44F5IN10O7
[ Molecular Weight ]:
1010.762