Desmethyl-QCA276

Names

[ Name ]:
Desmethyl-QCA276

Biological Activity

[Description]:

PROTAC BRD4-binding moiety 4 (compound 22) is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM. PROTAC BRD4-binding moiety 4 is a BET ligand for PROTAC which is an extremely potent BET degrader[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₇N₅OS

[ Molecular Weight ]:
387.46

[ Storage condition ]:
2-8°C

Desmethyl-QCA276

Names

Biological Activity

Chemical & Physical Properties

Related Compounds