DBCO-PEG4-VC-PAB-MMAE

Names

[ Name ]:
DBCO-PEG4-VC-PAB-MMAE

Biological Activity

[Description]:

DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Duocarmycins

[References]

[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₈H₁₂₈N₁₂O₁₉

[ Molecular Weight ]:
1658.03

Safety Information

[ Hazard Codes ]:
Xi

DBCO-PEG4-VC-PAB-MMAE

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds