AKR1C3-IN-6

Names

[ CAS No. ]:
2137881-54-8

[ Name ]:
AKR1C3-IN-6

Biological Activity

[Description]:

AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.31 μM (AKR1C3), 73.23 μM (AKR1C2)[1]


[In Vitro]

AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC50 of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1[1].

[References]

[1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15F3N4O3

[ Molecular Weight ]:
392.33

Related Compounds