Picrotin

Names

[ Name ]:
Picrotin

[Synonym ]:
(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
picrotoxin component 2
(-)-Picrotin

Biological Activity

[Description]:

Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

α2 GlyR, α1 GlyR, α3 GlyR[1][2]

[References]

[1]. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20.

[2]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9.

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
595.8ºC at 760 mmHg

[ Melting Point ]:
256-258ºC

[ Molecular Formula ]:
C₁₅H₁₈O₇

[ Molecular Weight ]:
310.29900

[ Flash Point ]:
228.9ºC

[ Exact Mass ]:
310.10500

[ PSA ]:
105.59000

[ Vapour Pressure ]:
1.12E-16mmHg at 25°C

[ Index of Refraction ]:
1.637

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ8800000

CHEMICAL NAME :: Picrotin

CAS REGISTRY NUMBER :: 21416-53-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H18-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,729,1968

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TJ8800000