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SH-42

Names

[ CAS No. ]:
2143952-36-5

[ Name ]:
SH-42

Biological Activity

[Description]:

SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: 42 nM (DHCR24)[1]


[References]

[1]. Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H38O4

[ Molecular Weight ]:
402.57

Related Compounds