Methyl2,5-dihydroxybenzoate

Names

[ Name ]:
Methyl2,5-dihydroxybenzoate

[Synonym ]:
2,5-dihydroxybenzoic acid methyl ester
2,5-dihydroxy-benzoic acid methyl ester
MFCD00016464
Benzoic acid, 2,5-dihydroxy-, methyl ester
Methyl2,5-dihydroxybenzoate
methyl 6-(trifluoromethylsulfonyloxy)coumarin-5-carboxylate
methyl 2,5-dihydroxy-benzoate
EINECS 218-427-8
Methyl 2,5-dihydroxybenzoate
Methyl Gentisate
Methyl-2,5-dihydroxybenzoate
Gentisic Acid Methyl Ester
Benzoic acid,2,5-dihydroxy-,methyl ester

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
328.2±22.0 °C at 760 mmHg

[ Melting Point ]:
86-88 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₄

[ Molecular Weight ]:
168.147

[ Flash Point ]:
137.6±15.8 °C

[ Exact Mass ]:
168.042252

[ PSA ]:
66.76000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.588

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors.

Biochem. Pharmacol. 57(6) , 663-72, (1999)

To discover safe and effective topical skin-lightening agents, we have evaluated alkyl esters of the natural product gentisic acid (GA), which is related to our lead compound methyl gentisate (MG), an...

Methyl 2, 5-dihydroxybenzoate. Brown CL, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 59(5) , 630-631, (2003)

Total Synthesis of (.+-.)-Euonyminol, the Sesquiterpenoid Nucleus of Cathedulin K-19, via an Epoxide Cascade Cyclization. White JD, et al.

J. Am. Chem. Soc. 117(38) , 9780-9781, (1995)