HS-1371

Names

[ CAS No. ]:
2158197-70-5

[ Name ]:
HS-1371

Biological Activity

[Description]:

HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> RIP kinase

Research Areas >> Infection

[Target]

IC50: 20.8 nM (RIP3)[1]

[In Vitro]

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines[1]. HS-1371 can block RIP3 S227 phosphorylation[1]. HS-1371 rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death[1].

[References]

[1]. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄N₄O

[ Molecular Weight ]:
384.47

[ Storage condition ]:
2-8℃

HS-1371

Names

Biological Activity

Chemical & Physical Properties

Related Compounds