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WY-135

Names

[ CAS No. ]:
2163060-83-9

[ Name ]:
WY-135

Biological Activity

[Description]:

WY-135 is a ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: 1.4 nM (ALK), 1.1 nM (ROS1)[1]


[References]

[1]. Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34ClN9O3S

[ Molecular Weight ]:
612.15

Related Compounds