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SIRT5 inhibitor

Names

[ CAS No. ]:
2166487-21-2

[ Name ]:
SIRT5 inhibitor

Biological Activity

[Description]:

SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Others

[Target]

IC50: 0.11 μM (Sirtuin)[1].


[In Vitro]

SIRT5 inhibitor (compound 49) is a very potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1[1].

[References]

[1]. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841.


[Related Small Molecules]

Selisistat (EX 527) | Nicotinamide | SRT1720 HCl | Sirtinol | 3-TYP | SRT 2104 | Fisetin | OSS_128167 | Thiomyristoyl | Cambinol | Tenovin-1 | CAY10602 | AK-7 | Inauhzin | Tenovin 6 Hydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C31H39FN6O6S2

[ Molecular Weight ]:
674.81

Related Compounds