NS3861
Names
[ CAS No. ]:
216853-60-0
[ Name ]:
NS3861
[Synonym ]:
3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene (2E)-2-butenedioate (1:1)
8-Azabicyclo[3.2.1]oct-2-ene, 3-(3-bromo-2-thienyl)-8-methyl-, (2E)-2-butenedioate (1:1)
Biological Activity
[Description]:
A potent, subtype-selective α3β4 nAChR partial agonist with Ki of 0.62 nM; selectively activates receptors containing β4- but not β2-subunits, shows no efficacy at α4β2 receptors and only marginal efficacy at α4β4 receptors expressed in oocytes; enhances fecal pellet expulsion in a dose-dependent manner in mice that received long-term, but not short-term, morphine treatment.
[References]
References 1. Harpsøe K, et al. J Biol Chem. 2013 Jan 25;288(4):2559-70. 2. Gade AR, et al. J Pharmacol Exp Ther. 2016 Jun;357(3):520-8. View Related Products by Target nAChR
Chemical & Physical Properties
[ Molecular Formula ]:
C12H14BrNS.C4H4O4
[ Molecular Weight ]:
400.287
[ Exact Mass ]:
399.013977