JAK-2/3-IN-2

Names

[ CAS No. ]:
2170398-48-6

[ Name ]:
JAK-2/3-IN-2

Biological Activity

[Description]:

JAK-2/3-IN-2 (Compound 3h) is a JAK2 and JAK3 inhibitor with IC50s of 23.85 nM and 18.9 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

JAK3:18.9 nM (IC50)

JAK2:23.85 nM (IC50)

[References]

[1]. Sanachai K, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega, 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₉ClN₂OS

[ Molecular Weight ]:
358.88

Related Compounds