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QPX7728-OH disodium

Names

[ CAS No. ]:
2170848-99-2

[ Name ]:
QPX7728-OH disodium

Biological Activity

[Description]:

QPX7728-OH disodium (compound 13) is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 13. QPX7728-OH disodium inhibits cleavage of Nitrocefin (HY-108913) by purified class A, C and D enzymes, with Kis less than 0.1 µΜ[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

QPX7728-OH disodium potentiates Aztreonam (HY-B0129) and Tigemonam (HY-U00380) against strains expressing class A and class C enzymes, with MICs≤5 µg/mL. QPX7728-OH disodium potentiates Biapenem (HY-13573) against strains expressing class A (KPC) or class D (OXA-48) carbapenemases, with MICs≤5 µg/mL[1].

[References]

[1]. Scott Hecker, et al. Boronic acid derivatives and therapeutic uses thereof. WO2018005662A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H6BFNa2O5

[ Molecular Weight ]:
281.94

Related Compounds