AGH-192

Names

[ Name ]:
AGH-192

Biological Activity

[Description]:

AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.AGH-192 displays excellent water solubility, high selectivity over related CNS targets, high metabolic stability, oral bioavailability and low cytotoxicity.AGH-192 could crosses blood-brain barrier to a high extent.AGH-192 alleviates the symptoms of neuropathic pain in a mouse model.

[References]

1. Adam S Hogendorf, et al. Eur J Med Chem. 2019 May 15;170:261-275.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁FIn₃

[ Molecular Weight ]:
355.155

Related Compounds

AGH-107
8-[[4-[3-[[3-[4-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]phenyl]carbamoylamino]phenyl]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
MI-192 HCl
Tyrosinase (192-200) (human, mouse) acetate salt
ML192
Cyclotriphosphazene-PMMH-192 Dendrimer
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
5-Bromo-2-(4-chloro-1H-pyrazol-1-yl)benzaldehyde
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1-(3-Chloropyridin-2-yl)propan-2-one
5-(3-ethyl-1-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-amine