UNC-2170 maleate
Names
[ CAS No. ]:
2173992-60-2
[ Name ]:
UNC-2170 maleate
[Synonym ]:
3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide (2Z)-2-butenedioate (1:1)
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-, (2Z)-2-butenedioate (1:1)
Biological Activity
[Description]:
A small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain; highly cell permeant with no significant measureable cellular efflux; shows modestly potent, demonstrates at least 17-fold selectivity for 53BP1 as compared to nine other Kme reader proteins.
[References]
References 1. Perfetti MT, et al. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. View Related Products by Target MDM2-p53
Chemical & Physical Properties
[ Molecular Formula ]:
C18H25BrN2O5
[ Molecular Weight ]:
429.306
[ Exact Mass ]:
428.094666