5-Demethylsinensetin

Names

[ Name ]:
5-Demethylsinensetin

[Synonym ]:
5-demethylsinensetin
5-Hydroxy-3',4',6,7-tetramethoxyflavone
HTMF
3'-O-methyleupatorin
6,7,4',5'-tetramethoxy-5-monohydroxyflavone
5-desmethylsinensetin

Biological Activity

[Description]:

5-desmethylsinensetin, isolated from Stevia satureiifolia var. satureiifolia, possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. María Florencia Beer, et al. Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifolia. Pharm Biol. 2016 Oct;54(10):2188-95.

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
556.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₁₈O₇

[ Molecular Weight ]:
358.34200

[ Flash Point ]:
200.7ºC

[ Exact Mass ]:
358.10500

[ PSA ]:
87.36000

[ LogP ]:
3.20000

[ Vapour Pressure ]:
5.27E-13mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%