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TLR7/8/9-IN-1

Names

[ CAS No. ]:
2180127-82-4

[ Name ]:
TLR7/8/9-IN-1

Biological Activity

[Description]:

TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9).

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[References]

[1]. Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H37N3O2

[ Molecular Weight ]:
435.61

[ Storage condition ]:
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO


Related Compounds