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Cassiaside B2

Names

[ CAS No. ]:
218155-40-9

[ Name ]:
Cassiaside B2

Biological Activity

[Description]:

Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist[1][2].[3]..

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Pradeep Paudel, et al. Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. ACS Omega. 2019 Jul 3;4(7):11621-11630.

[2]. S Kitanaka, et al. Antiallergic agent from natural sources. Structures and inhibitory effect of histamine release of naphthopyrone glycosides from seeds of Cassia obtusifolia L. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1650-2.

[3]. Heidi Yuen, et al. Mechanisms of Action of Cassiae Semen for Weight Management: A Computational Molecular Docking Study of Serotonin Receptor 5-HT2C. Int J Mol Sci. 2020 Feb 16;21(4):1326.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H52O25

[ Molecular Weight ]:
920.82

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds