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BDNF(human)

Names

[ CAS No. ]:
218441-99-7

[ Name ]:
BDNF(human)

[Synonym ]:
REC BRAIN-DERIVED NEUROTROPHIC FACTOR (HUMAN)

Biological Activity

[Description]:

BDNF (human) is a neurotrophin in the central nervous system and mediates survival and differentiation of neurons. BDNF (human) binds to TrkB and leads to the dimerization and autophosphorylation of tyrosine residues in the intracellular domain of the receptor. BDNF (human) can be used for study of neurodegenerative and psychiatric disorder[1][2].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
Research Areas >> Neurological Disease

[Target]

IC50: TrkB[1]


[References]

[1]. Robert H Lipsky, et al. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann N Y Acad Sci

[2]. A Cattaneo, et al. The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders. Transl Psychiatry

Chemical & Physical Properties

[ Storage condition ]:
−20°C

Safety Information

[ WGK Germany ]:
3

Related Compounds