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Disitamab

Names

[ CAS No. ]:
2185868-98-6

[ Name ]:
Disitamab

Biological Activity

[Description]:

Disitamab (RC48-0) is a humanized monoclonal antibody targeting HER2. Disitamab can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin (Disitamab vedotin (HY-P9985))[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

HER2


[In Vivo]

Disitamab（27 mg/kg；i.v.；一次；5 mL/kg）对猴子没有显着毒性[1]。

[References]

[1]. Jiang J, et al. Preclinical safety profile of disitamab vedotin：a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds