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Compound 919278

Names

[ CAS No. ]:
2189366-77-4

[ Name ]:
Compound 919278

Biological Activity

[Description]:

LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 10 μM (LTβR，p52 translocation)[1]


[References]

[1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541).

Chemical & Physical Properties

[ Molecular Formula ]:
C18H16N4O2

[ Molecular Weight ]:
320.35

Related Compounds