Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

Names

[ CAS No. ]:
2204226-02-6

[ Name ]:
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

[Synonym ]:
MFCD32063469

Biological Activity

[Description]:

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃ClN₄O₇

[ Molecular Weight ]:
454.86

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds