MMPSI

Names

[ CAS No. ]:
220509-74-0

[ Name ]:
MMPSI

[Synonym ]:
(S)-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin
(S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
5-((S)-2-Methoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
(S)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione
5-(S)-(2-methoxymethyl)pyrrolidinylsulfonyl isatin
(S)-(+)-5-[2-methoxymethylpyrrolidin-1-ylsulfonyl]isatin
(S)-5-[(2-methoxymethylpyrrolidin-1-yl)sulfonyl]isatin

Biological Activity

[Description]:

MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> Caspase

[Target]

human Caspase-3:1.7 μM (IC50)

[References]

[1]. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆N₂O₅S

[ Molecular Weight ]:
324.35

[ Exact Mass ]:
324.07800

[ PSA ]:
101.16000

[ LogP ]:
1.77760