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Fluticasone dimer impurity

Names

[ CAS No. ]:
220589-37-7

[ Name ]:
Fluticasone dimer impurity

[Synonym ]:
Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-6,9-difluoro-17-[[(fluoromethyl)thio]carbonyl]-11-hydroxy-16-methyl-3-oxoandrosta- 1,4-dien-17-yl ester, (6α,11β,16α,17α)-
6,9-difluoro-17-(((fluoromethyl)sulfanyl)carbonyl)-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylate
1V165RFB9Y
(6α,11β,16α,17α)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl (6α,11β,16α,17α)-6,9-difluoro-11,17-dihydroxy-16-met&#xD; hyl-3-oxoandrosta-1,4-diene-17-carboxylate

Biological Activity

[Description]:

Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate[1]. Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity[2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. The synthetic method of fluticasone propionate impurity. CN110105419A.

[2]. Jarvis B, et al. Inhaled fluticasone propionate: a review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs. 1999;57(5):769-803.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
823.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C43H51F5O8S

[ Molecular Weight ]:
822.917

[ Flash Point ]:
451.7±34.3 °C

[ Exact Mass ]:
822.322510

[ LogP ]:
4.66

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
-20°C


Related Compounds