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Florfenicol-d3

Names

[ CAS No. ]:
2213400-85-0

[ Name ]:
Florfenicol-d3

[Synonym ]:
MFCD15071228
FLORFENICOL-D3
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-{4-[(2H3)methylsulfonyl]phenyl}-2-propanyl]acetamide
Acetamide, 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methyl-d3-sulfonyl)phenyl]ethyl]-

Biological Activity

[Description]:

Florfenicol-d3 ((-)-Florfenicol-d3) is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213.

[2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
617.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H11D3Cl2FNO4S

[ Molecular Weight ]:
361.232

[ Flash Point ]:
327.3±31.5 °C

[ Exact Mass ]:
360.019287

[ LogP ]:
-0.12

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.548

Related Compounds