LIMK1 and 2 dual inhibitor

Names

[ Name ]:
LIMK1 and 2 dual inhibitor

Biological Activity

[Description]:

LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM); inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.

[References]

References 1. US Patent WO 2018055097. View Related Products by Target LIM Kinase (LIMK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₁F₃N₆O₃S₂

[ Molecular Weight ]:
610.63

Related Compounds

benzyl and 2,4-dimethylbenzyl ether of hydroquinone
Pim1/AKK1-IN-1
ACHP (Hydrochloride)
N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide
Cdk1/2 Inhibitor III
Bcl-2 Inhibitor
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
tert-butyl N-(1-cyclohexyl-3-methyl-1-oxobutan-2-yl)carbamate
2-Pyridinamine,5-chloro-N-[(4-methylphenyl)methyl]
(4-Methyl-tetrahydro-furan-2-yl)-methanol
1-(2,7-Dichloro-4-quinazolinyl)-4-piperidinecarboxamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde